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In conclusion, this study provides the first experimental evidence that mycotoxins directly disrupt glycolytic metabolism and subsequently suppress histone lactylationa previously unrecognized epigenetic mechanism driving cell ferroptosis

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent

Specific pathways affected include TGF-beta superfamily signaling, Wnt signaling, antioxidant defense (including superoxide dismutase, glutathione S-transferases, and thioredoxin reductase), and DNA repair mechanisms

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In B-type PACs, the linkage between the successive monomeric units is usually between the C4 position of the upper unit and the C8 or C6 position of the lower unit